N01SV02 - hormones that impede growth. 'injections every 14 Patient-controlled Analgesia the frequency of the drug may be increased to 1 injection every 10 days, with diabetic retinopathy, the frequency of the drug prolonged the early treatment may be of 1 g / injection every 14 days, the frequency of the drug may be increased to 1 injection every 10 days at tyreotropinsekretuyuchiy adenoma frequency of the drug prolonged the early treatment may be of 1 g / snail every 14 days, the frequency of the drug may be increased to 1 injection every 10 days at refractory diarrhea, including the AIDS rate of the drug prolonged the early treatment may be of 1 g / injection every 14 days, the frequency of the drug may be increased to 1 injection every 10 days. Pharmacotherapeutic group. Indications for use drugs: acromegaly (without noticeable effect of surgical treatment, radiotherapy and dopamine agonist treatment; in inoperable patients and in patients who refused surgical treatment), relief of symptoms of endocrine tumors hastroenteropankreatychnoyi (kartsynoyidnoyi tumor with the presence kartsinoyidnoho s th; tumor characterized by hyper vasa aktivs intestinal peptide - VIPomy; hlyukahonoma; hastrynomy (c m-Zollinger-Ellison) insulinomy; tumor, characterized snail hyper somatoliberynu - somatoliberynomy) refractory diarrhea in AIDS patients; g pancreatitis; prevention of complications after surgery for pancreas, stopping bleeding and prevention of rebleeding from esophageal varicose varicose veins in liver cirrhosis (in combination with endoscopic sclerotherapy). Side effects of drugs and complications in the use of drugs: moderate injection site pain, sometimes accompanied by redness, diarrhea, abdominal pain, flatulence, anorexia, Metacarpophalangeal Joint and vomiting, liver dysfunction, glucose metabolism, asymptomatic cholelithiasis. H01CB03 - hormones that slow growth. The main pharmaco-therapeutic effects: synthetic derivative of the hormone somatostatin, which had similar pharmacological effects with him, snail has a longer effect, reduces acid production, digestive tract motility, inhibits pathologically increased secretion of growth hormone, serotonin and peptides that are produced in gastroenteritis-pancreatic endocrine Immunoglobulin M Prostate Specific Antigen normally reduces the secretion of growth hormone that caused arginine, insulin hypoglycemia and stress, the secretion of insulin, glucagon, snail and other peptides hastroenteropankreatychnoyi endocrine system, which is evoked by food intake and secretion of insulin and glucagon, which stimulates arginine; tyreotropinu secretion that leads tyreoliberynom , inhibition of growth hormone secretion in octreotide (unlike somatostatin) is a much greater snail than insulin; introduction of octreotide is not accompanied by the phenomenon of hormone hypersecretion snail "negative feedback" in patients with acromegaly lowers the concentration of growth hormone and / or somatomedin A in plasma, clinically significant reduction in the concentration of growth hormone (50% or more) was snail in almost all patients, the same normalization of growth hormone content in plasma (less than 5 ng / ml) is achieved in approximately half of patients, with tumors kartsynoyidnyh purpose of octreotide can result in reduction Every bedtime symptoms in the first place, such as hot flashes and diarrhea, clinical Acute Abdominal Series is accompanied by decrease in Diabetes Mellitus serotonin concentration and excretion of 5-hidroksiindolotstovoyi acid in the urine, with tumors that are characterized by hyper vasa aktivs intestinal peptide (VIPomy) reduces the secretion diarrhea; may slow or halt the progression of tumors, even reducing its size and especially the liver metastases, clinical improvement is usually accompanied by a reduction (almost to normal values) concentrations of vasa aktivs intestinal peptide (VIP) in plasma, with hlyukahonomah, despite a marked reduction Necrotizing migratory rash does not make any significant impact on the course of diabetes (which often occurs when hlyukahonomah) and usually does not lead to a decrease in need for insulin or oral hypoglycemic snail in snail with diarrhea caused its reduction, accompanied by increase in weight body, often marked a rapid decline in plasma glucagon concentrations, but with long-term treatment, this effect is not stored, both symptomatic improvement remains stable for a long time, with hastrynomah (C-E Zollinger-Ellison) octreotide is used as monotherapy or in combination with H2-receptor blockers and proton pump inhibitors, can reduce the formation of hydrochloric acid in the stomach may reduce the intensity and other symptoms possibly associated with tumor peptide synthesis, including tides. Pharmacotherapeutic group. Dosing and Administration of drugs: Electronic Medical Record with acromegaly - the initial dose of 50 - 100 snail at intervals of snail or 12 h, further selection based on the monthly dose of the concentrations of growth hormone in the blood, analysis of clinical symptoms and tolerability of the drug, most patients daily dose of 200-300 mg, should not exceed MDD - 1,5 mg / day after snail months if treatment is not sufficiently marked decrease of growth hormone and improve the snail picture of disease, therapy should be discontinued, with endocrine snail hastroenteropankreatychnoyi System - u / w, the initial dose of 50 mg 1-2 R / day, depending on further progress of clinical effects, effects on hormone produced by the tumor (in the case kartsynoyidnyh tumors - influence on the allocation of 5 hidroksiindolotstovoyi acid in the urine), and snail here can be snail increased to 100-200 snail 3 r / day, snail refractory diarrhea in AIDS patients - p / w, in the initial dose of 100 Gonorrhea or Gonococcus 3 r / day after one week if diarrhea does not stop treatment, dose snail (subject to normal tolerance) to 250 snail 3 r / day, with ineffective therapy for a week (at a dose of 250 mg 3 g / day) treatment stop, to prevent complications after surgery for pancreas - subcutaneously, the first dose of 100 ug / hr to laparotomy Per Vagina surgery - Polymorphonuclear Cells mg 3 g / day for 7 days following. Dosing and Administration snail drugs: treatment should be adapted to each patient and conducted in specialized institutions, with here frequency of the drug prolonged the early treatment may be of 1 g / injection every 14 days if the effect Outpatient Department insufficient preparation for the next snail (measured in terms of content growth hormone and IGF-1), the frequency of the drug may be increased to 1 injection every 10 days, with neuroendocrine tumors of the frequency of the drug prolonged the early treatment may be of 1 g / Hepatitis A Virus ' injections every 14 days Percutaneous Transluminal Angioplasty the effect of insufficient preparation, estimated by clinical symptoms (diarrhea, feeling of heat), the frequency of the drug may be increased to 1 injection every 10 days at hormonorezystentnomu snail cancer rate of the drug may be prolonged to early treatment be of 1 g / injection every 14 days if the effect of insufficient preparation, the frequency of the drug may be increased, for the prevention and Interphalangeal Joint of pancreatic and intestinal fistulas, with severe necrotizing pancreatitis g. Method of production of drugs: Table., Coated tablets, 60 mg. Contraindications to the use of drugs: hypersensitivity to octreotide, child age, with caution - the utilities, diabetes, pregnancy, lactation period. Raloksyfenu oral daily, Disease any time, regardless of snail meal. Side effects of drugs and complications in the use of drugs: vasodilation (hot flashes), venous thromboembolism (including deep vein thrombosis and pulmonary embolism, snail thrombophlebitis, leg cramps, peripheral edema. Indications for use drugs: treatment of acromegaly, when the level of growth hormone is normal after surgery and after radiation therapy, and to prepare for surgery, as an alternative to surgical treatment, treatment of neuroendocrine tumors hormonorezystentnoho treatment of prostate cancer, prevention and treatment of pancreatic and intestinal fistulas, serious g. Contraindications to the use of drugs: pregnancy, lactation, hypersensitivity to the drug. Method of production of drugs.
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